The ability to adapt successfully to changing environments and stressors is balanced in large part by the body’s immune and endocrine systems, which share a highly connected cross-regulatory relationship. In women these two systems are particularly integrated as they cooperate to control reproductive function necessary for pregnancy tolerance. Our understanding of the factors governing this critical and complex relationship is poor, but it would allow us to make better sense of the sex-discrepant prevalence of certain autoimmune disorders, such as lupus and multiple sclerosis, and bone fragility disorders, such as osteoporosis, both of which have female sex as the greatest predictive risk factor. My aim as a translational scientist is to deepen understanding of this intricate immune-endocrine link that confers optimal bone health, metabolism and reproductive function.
See Professor Kalyan’s publications here
1: Gajic-Veljanoski O, Papaioannou A, Kennedy C, Ioannidis G, Berger C, Wong AKO, Rockwood K, Kirkland S, Raina P, Thabane L, Adachi JD; CaMos Research Group. Osteoporotic fractures and obesity affect frailty progression: a longitudinal analysis of the Canadian multicentre osteoporosis study. BMC Geriatr. 2018 Jan 5;18(1):4.
2: Prior JC, Seifert-Klauss VR, Giustini D, Adachi JD, Kalyan S, Goshtasebi A. Estrogen-progestin therapy causes a greater increase in spinal bone mineral density than estrogen therapy – a systematic review and meta-analysis of controlled trials with direct randomization. J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):146-154.
3: Kalyan S, Patel MS, Kingwell E, Côté HCF, Liu D, Prior JC. Competing Factors Link to Bone Health in Polycystic Ovary Syndrome: Chronic Low-Grade Inflammation Takes a Toll. Sci Rep. 2017 Jun 13;7(1):3432.
4: Kalyan S. Romosozumab Treatment in Postmenopausal Osteoporosis. N Engl J Med. 2017 Jan 26;376(4):395-6.
5: Kalyan S. It May Seem Inflammatory, but Some T Cells Are Innately Healing to the Bone. J Bone Miner Res. 2016 Nov;31(11):1997-2000.
6: Kalyan S, Wang J, Quabius ES, Huck J, Wiltfang J, Baines JF, Kabelitz D. Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw. J Transl Med. 2015 Jul 4;13:212.