Clinical Associate Professor
Pathology and Laboratory Medicine
Division Head, Clinical Chemistry, St. Paul’s Hospital
, 2001, MD
, 2006, FRCPC

Mass spectrometric analysis of plasma mineralocorticoids

Mass spectrometric analysis of the renin angiotensin aldosterone system


1. Van Der Gugten JG, Crawford M, Grant RP, Holmes DT. Supported liquid extraction offers improved sample preparation for aldosterone analysis by liquid chromatography tandem mass spectrometry. J Clin Pathol. 2012 Aug 4.

2. Van Der Gugten JG, Dubland J, Liu HF, Wang A, Joseph C, Holmes DT. Determination of serum aldosterone by liquid chromatography and tandem mass spectrometry: a liquid-liquid extraction method for the ABSCIEX API-5000 mass spectrometry system. J Clin Pathol. 2012 May;65(5):457-62.

3. Van Der Gugten JG, Holmes DT. Plasma Renin Activity by Tandem Mass Spectrometry Employing Analyte Immunoprotection. American Society for Mass Spectrometry Meeting. Vancouver, BC. 2012.

4. Reid JD, Holmes DT, Mason DR, Shah B, Borchers CH. Towards the development of an immuno MALDI (iMALDI) mass spectrometry assay for the diagnosis of hypertension. J Am Soc Mass Spectrom. 2010 Oct;21(10):1680-6.

5. Mason DR, Reid JD, Camenzind AG, Holmes DT, Borchers CH. Duplexed iMALDI for the detection of angiotensin I and angiotensin II. Methods. 2012 Feb;56(2):213-22.

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