The ability to adapt successfully to changing environments and stressors is balanced in large part by the body’s immune and endocrine systems, which share a highly connected cross-regulatory relationship. In women these two systems are particularly integrated as they cooperate to control reproductive function necessary for pregnancy tolerance. Our understanding of the factors governing this critical and complex relationship is poor, but it would allow us to make better sense of the sex-discrepant prevalence of certain autoimmune disorders, such as lupus and multiple sclerosis, and bone fragility disorders, such as osteoporosis, both of which have female sex as the greatest predictive risk factor. My aim as a translational scientist is to deepen understanding of this intricate immune-endocrine link that confers optimal bone health, metabolism and reproductive function.
See Professor Kalyan’s publications here
1. Kalyan S, Wang J, Quabius ES, Huck J, Wiltfang J, Baines JF, Kabelitz D. Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw. Journal of Translational Medicine, 2015, July; 13:212-225.
2. Chandrasekaran V*, Kalyan S*, Biehl V, Lettau M, Nerdal PT, Oberg H-H, Wesch D, Lindhorst T, Kabelitz D. Novel synthesis of fluorochrome-coupled zoledronate with preserved functional activity on gamma/delta T cells and tumor cells. MedChemComm, 2015, advance online publication March 30.
3. Wang J, Kalyan S, Steck N, Turner L, Harr B, Künzel S, Vallier M, Häsler R, Franke A, Oberg H-H, Ibrahim S, Grassl G, Kabelitz D, Baines J. Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome. Nature Communications, 2015, Mar; article #6440.
4. Fazio J, Kalyan S, Wesch D, Kabelitz D. Inhibition of human γδ T cell proliferation and effector functions by neutrophil serine proteases. Scandinavian Journal of Immunlogy. 2014, Dec;80(6):381-9.
5. Kalyan S, Huebbe P, Esatbeyoglu T, Niklowitz P, Côté HCF, Rimbach G, Kabelitz D. Nitrogen-bisphosphonate therapy linked to compromised coenzyme Q10 and vitamin E status in postmenopausal women. Journal of Clinical Endocrinology and Metabolism. 2014, Apr;99(4):1307-13.
6. Kalyan S, & Kabelitz D. When neutrophils meet T cells: beginnings of a tumultuous relationship with under-appreciated potential. European Journal of Immunology. 2014, Mar;44(3):627-33.
7. Kalyan S, Chandrasekaran V, Quabius ES, Lindhorst TK, and Kabelitz D. Nitrogen-bisphosphonate uptake by neutrophils leads to the suppression of human peripheral blood γδ T cells. Cellular and Molecular Life Sciences. 2014, Jun;71(12):2335-46.